Author

T. S. Freedman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

B. F. Brian· 3 shared J. T. Greene· 2 shared M. G. Nunez· 2 shared A. Barkhymer· 1 shared A. M. Weiler· 1 shared A. R. Thompson· 1 shared A. Richardon· 1 shared A. S. Jaeger· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

B. F. Brian

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

D. M. Rasmussen, M. M. Semonis, J. T. Greene, J. M. Muretta, A. R. Thompson, S. T. Ramos, D. D. Thomas, W. C. K. Pomerantz, T. S. Freedman, N. M. Levinson

The paper explains how type II RAF inhibitors paradoxically activate BRAF by inducing asymmetric dimerization, using biophysical and structural methods.

bioRxiv · Apr 18, 2023Biophysics

Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

A. S. Jaeger, C. M. Crooks, A. M. Weiler, M. I. Bliss, S. L. Rybarczyk, A. Richardon, M. Einwalter, E. Peterson, S. Capuano, A. Barkhymer, J. T. Becker, J. T. Greene, T. S. Freedman, R. A. Langlois, T. C. Friedrich, M. T. Aliota

This study shows that ZIKV infection protects against SPONV in rhesus macaques, but not vice versa, suggesting one-way cross-protection between the viruses.

bioRxiv · Dec 16, 2022Microbiology

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

B. F. Brian, F. V. Sjaastad, T. S. Freedman

This study identifies SH3-domain mutations in Csk that selectively disrupt homodimerization or PTPN22 binding, showing both impair Csk's negative regulatory function in cells.

bioRxiv · Jan 13, 2022Biochemistry

Splice-specific lyn knockout mice reveal a dominant function of LynB in preventing autoimmunity

B. F. Brian, M. L. Sauer, B. L. Ruis, J. L. Auger, S. E. Senevirathne, W. L. Swanson, M. G. Nunez, B. S. Moriarity, C. A. Lowell, B. A. Binstadt, T. S. Freedman

This study shows that LynB, a splice variant of Lyn, prevents autoimmunity, while its absence leads to TLR4 hyper-responsiveness and lupus-like disease.

bioRxiv · May 3, 2021 · PreprintImmunology

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

B. F. Brian, A. S. Jolicoeur, C. R. Guerrero, M. G. Nunez, Z. E. Sychev, S. A. Hegre, P. Satrom, N. Habib, J. M. Drake, K. L. Schwertfeger, T. S. Freedman

The paper identifies how LynA is selectively degraded in macrophages via c-Cbl targeting tyrosine 32, while mast cells, with low c-Cbl, maintain high LynA levels, affecting signaling.

bioRxiv · Jul 2, 2019Biochemistry