Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression
M. R. Pandkar, S. Sinha, A. Samaiya, S. Shukla
This study identifies lactate-driven histone lactylation as a mechanism enhancing c-Myc expression and promoting breast cancer progression through SRSF10-mediated alternative splicing.
bioRxiv · May 14, 2023Cancer Biology