Author

A. Scasny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Assay:proteomics· 3 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. E. Vidal· 6 shared B. Alibayov· 4 shared F. Khan· 3 shared L. S. McDaniel· 3 shared A. G. Jop Vidal· 2 shared A. G. Vidal· 2 shared E. McDevitt· 2 shared L. Murin· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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6 shared papersMicrobiology

J. E. Vidal

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Author profile →

6 papers

Recent·Most cited

Heme-Mediated Selection of Encapsulated Streptococcus pneumoniae in the Lungs by Oxidative Stress

B. Alibayov, A. G. Jop Vidal, L. Murin, A. Scasny, K. Takeshita, K. Beaton, K. Edwards, T. Punshon, B. Jackson, L. S. McDaniel, J. E. Vidal

This study shows that heme from oxidized hemoglobin promotes the selection of encapsulated Streptococcus pneumoniae in the lungs, linking oxidative stress to pneumococcal pneumonia pathogenesis.

bioRxiv · Nov 14, 2023Microbiology

Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells

A. Scasny, B. Alibayov, F. Khan, S. Rao, L. Murin, A. G. Vidal, P. Smith, L. Wei, K. S. Edwards, K. Warncke, J. E. Vidal

This study shows that Streptococcus pneumoniae produces H2O2, which oxidizes hemoproteins like hemoglobin and cytochrome c, leading to mitochondrial dysfunction and cell death in human lung cells.

bioRxiv · Jun 7, 2023 · PreprintMicrobiology

Oxidative reactions catalyzed by hydrogen peroxide produced by Streptococcus pneumoniae and other Streptococci Cause the Release and Degradation of Heme from Hemoglobin

B. Alibayov, A. Scasny, F. Khan, A. Creel, P. Smith, A. G. Jop Vidal, F. M. Fitisemanu, T. Teresita Padilla-Benavides, J. N. Weiser, J. E. Vidal

bioRxiv · Aug 23, 2022Microbiology

Synergistic protection against secondary pneumococcal infection by human monoclonal antibodies targeting distinct epitopes

A. D. Gingerich, F. Royer, A. L. McCormick, A. Scasny, J. E. Vidal, J. Mousa

This paper demonstrates that two human monoclonal antibodies targeting distinct epitopes of pneumococcal surface protein PhtD synergistically protect against secondary pneumococcal infection in a mouse model.

bioRxiv · Apr 20, 2022Immunology

Prophylactic inhibition of colonization by Streptococcus pneumoniae with the secondary bile acid metabolite deoxycholic acid

J. E. Vidal, M. N. Wier, U. Angulo-Zamudio, E. McDevitt, A. G. Vidal, B. Alibayov, A. Scasny, S. M. Wong, B. J. Akerley, L. S. McDaniel

This study shows deoxycholic acid eradicates Streptococcus pneumoniae colonization in vitro and in vivo, with no observed resistance.

bioRxiv · May 17, 2021Microbiology

Hydrogen peroxide production by Streptococcus pneumoniae results in alpha-hemolysis by oxidation of oxy-hemoglobin to met-hemoglobin

E. McDevitt, F. Khan, A. Scasny, Z. Eichembaun, L. S. McDaniel, J. E. Vidal

This paper shows that Streptococcus pneumoniae produces hydrogen peroxide, which oxidizes oxy-hemoglobin to met-hemoglobin, causing the greenish -hemolysis halo on blood agar plates, not pneumolysin.

bioRxiv · Jul 23, 2020Microbiology