Author

A. Shibai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

C. Furusawa· 3 shared H. Kotani· 3 shared J. Iwasawa· 1 shared M. Izutsu· 1 shared M. Kawada· 1 shared N. Sakata· 1 shared S. Tsuru· 1 shared T. Maeda· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 17 mutual co-author links

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3 shared papersEvolutionary Biology

C. Furusawa

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3 papers

Recent·Most cited

Non-monotonic Relationship between Mutation Rate and Speed of adaptation under Antibiotic Exposure in Escherichia coli

A. Shibai, M. Izutsu, H. Kotani, C. Furusawa

This study shows that higher mutation rates in E. coli do not always speed up antibiotic resistance evolution, revealing a non-monotonic relationship that varies by antibiotic type.

bioRxiv · Aug 15, 2023 · PreprintEvolutionary Biology

Multi-dimensional antibiotic resistance time series reveals the phenotype-based fitness landscape for Escherichia coli

J. Iwasawa, T. Maeda, A. Shibai, H. Kotani, M. Kawada, C. Furusawa

The paper infers a phenotype-based fitness landscape for antibiotic resistance in Escherichia coli using multi-dimensional time-series drug resistance data to predict evolutionary trajectories.

bioRxiv · Aug 23, 2022 · PreprintEvolutionary Biology

Purifying selection enduringly acts on the sequence evolution of highly expressed proteins in Escherichia coli

A. Shibai, H. Kotani, N. Sakata, C. Furusawa, S. Tsuru

This study shows the E-R anticorrelation holds in both past and de novo microevolution in E. coli, confirming ongoing purifying selection on highly expressed genes.

bioRxiv · Mar 2, 2022Evolutionary Biology