C. Furusawa

Laboratory evolution of the bacterial genome structure through insertion sequence activation

This study accelerates bacterial genome evolution by introducing multiple insertion sequences into E. coli, resulting in significant genome rearrangements and size changes.

Promoters constrain evolution of expression levels of essential genes inEscherichia coli

The paper investigates how promoter variability affects the evolution of essential genes in E. coli, finding that promoters of essential genes show biased mutational variability toward lower activity, constraining future expression level evolution.

Genetic properties underlying transcriptional variability across different perturbations

The paper investigates how gene regulatory networks influence transcriptional variability in Escherichia coli under different perturbations and identifies genetic properties that explain gene-to-gene differences in transcriptional variation.

Non-monotonic Relationship between Mutation Rate and Speed of adaptation under Antibiotic Exposure in Escherichia coli

This study shows that higher mutation rates in E. coli do not always speed up antibiotic resistance evolution, revealing a non-monotonic relationship that varies by antibiotic type.

Evolution of hierarchy and irreversibility in theoretical cell differentiation model

This study shows that hierarchy and irreversibility in cell differentiation emerge naturally in a mathematical model as the number of terminal states increases, without requiring adaptive selection.

Multi-dimensional antibiotic resistance time series reveals the phenotype-based fitness landscape for Escherichia coli

The paper infers a phenotype-based fitness landscape for antibiotic resistance in Escherichia coli using multi-dimensional time-series drug resistance data to predict evolutionary trajectories.

Purifying selection enduringly acts on the sequence evolution of highly expressed proteins in Escherichia coli

This study shows the E-R anticorrelation holds in both past and de novo microevolution in E. coli, confirming ongoing purifying selection on highly expressed genes.

Single mutation makes Escherichia coli an insect mutualist

The paper shows that a single mutation in E. coli enables it to become an insect mutualist by disrupting carbon catabolite repression.

High-throughput laboratory evolution and evolutionary constraints in Escherichia coli

This study uses high-throughput lab evolution of E. coli to identify evolutionary constraints and trade-offs in antibiotic resistance.

Formation Of Dominant Mode By Evolution In Biological Systems

The paper investigates how evolutionary robustness constrains phenotypic changes to a one-dimensional axis related to growth rate in bacterial cells.