Author

H. Kotani

The University of Tokyo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 4 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

C. Furusawa· 4 shared A. Shibai· 3 shared J. Iwasawa· 2 shared M. Kawada· 2 shared N. Sakata· 2 shared T. Maeda· 2 shared A. Maeda· 1 shared A. Sakai· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersEvolutionary Biology

C. Furusawa

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity

T. Hsu, Xi Wang, Jiayan Zhang, Yukari Isayama, Viktoria E. M. Schindler, Eveline Van Gompel, Hadil Maadadi, Celia Torres-Arancivia, Akiko Shimazaki-Takahashi, Nina Kurihara, Mariko Kondo, Marina Galesic, Antonella Notarnicola, Sharmin Sultana, A. Maeda, , Sun Hur

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

bioRxiv · Jul 31, 2026 · PreprintBiochemistry✦ In-depth digest

Non-monotonic Relationship between Mutation Rate and Speed of adaptation under Antibiotic Exposure in Escherichia coli

A. Shibai, M. Izutsu, H. Kotani, C. Furusawa

This study shows that higher mutation rates in E. coli do not always speed up antibiotic resistance evolution, revealing a non-monotonic relationship that varies by antibiotic type.

bioRxiv · Aug 15, 2023 · PreprintEvolutionary Biology

Multi-dimensional antibiotic resistance time series reveals the phenotype-based fitness landscape for Escherichia coli

J. Iwasawa, T. Maeda, A. Shibai, H. Kotani, M. Kawada, C. Furusawa

The paper infers a phenotype-based fitness landscape for antibiotic resistance in Escherichia coli using multi-dimensional time-series drug resistance data to predict evolutionary trajectories.

bioRxiv · Aug 23, 2022 · PreprintEvolutionary Biology

Purifying selection enduringly acts on the sequence evolution of highly expressed proteins in Escherichia coli

A. Shibai, H. Kotani, N. Sakata, C. Furusawa, S. Tsuru

This study shows the E-R anticorrelation holds in both past and de novo microevolution in E. coli, confirming ongoing purifying selection on highly expressed genes.

bioRxiv · Mar 2, 2022Evolutionary Biology

Circumstances and factors of sleep-related sudden infant deaths in Japan

M. Osawa, Y. Ueno, N. Ikeda, K. Ikematsu, T. Yamamoto, W. Irie, S. Kozawa, H. Kotani, H. Hamayasu, T. Murase, K. Shingu, M. Sugimoto, R. Nagao, Y. Kakimoto

This study investigates recent trends and risk factors of sleep-related sudden infant deaths in Japan, identifying high odds ratios for teenage mothers and later birth order.

bioRxiv · May 4, 2020Pathology

High-throughput laboratory evolution and evolutionary constraints in Escherichia coli

T. Maeda, J. Iwasawa, H. Kotani, N. Sakata, M. Kawada, T. Horinouchi, A. Sakai, K. Tanabe, C. Furusawa

This study uses high-throughput lab evolution of E. coli to identify evolutionary constraints and trade-offs in antibiotic resistance.

bioRxiv · Feb 19, 2020Evolutionary Biology