N. Sakata

Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumor

A low carbohydrate diet suppresses neuroendocrine tumor onset and progression by reducing insulin signaling and PI3K-Akt-mTOR pathway activity in mouse models and correlates with better prognosis in patients.

Controlling stomatal aperture, a potential strategy for managing plant bacterial disease

The paper shows that applying certain amino acids reduces bacterial blight in cabbage by inducing stomatal closure, limiting bacterial entry.

Purifying selection enduringly acts on the sequence evolution of highly expressed proteins in Escherichia coli

This study shows the E-R anticorrelation holds in both past and de novo microevolution in E. coli, confirming ongoing purifying selection on highly expressed genes.

Covering soybean leaves with cellulose nanofiber changes leaf surface hydrophobicity and confers resistance against Phakopsora pachyrhizi

This study shows that covering soybean leaves with cellulose nanofiber reduces disease severity caused by Phakopsora pachyrhizi by altering leaf hydrophobicity and suppressing pathogen-related gene expression.

Coronatine contributes Pseudomonas cannabina pv. alisalensis virulence by overcoming both stomatal and apoplastic defenses in dicot and monocot plants

Acibenzolar-S-methyl activates stomatal-based defense systemically in Japanese radish by inducing peroxidase-dependent reactive oxygen species production

This study shows ASM activates systemic acquired resistance in Japanese radish by inducing peroxidase-dependent ROS production, leading to stomatal closure and reduced bacterial disease.

High-throughput laboratory evolution and evolutionary constraints in Escherichia coli

This study uses high-throughput lab evolution of E. coli to identify evolutionary constraints and trade-offs in antibiotic resistance.