A. Shimon

Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity

The paper redesigns the active site of lactonase SsoPox to enhance phosphotriester catalytic activity, revealing that loop conformation changes are critical for activity shifts.

Coronacept - a potent immunoadhesin against SARS-CoV-2

The paper describes the design of a modified human ACE2 immunoadhesin with enhanced affinity for SARS-CoV-2 spike protein, showing its potential as an antiviral agent.