Author

P. Jacquet

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Stephanou· 2 shared A. Jenks· 1 shared A. Shimon· 1 shared Alexandre AppolaireiD· 1 shared Antoine RoyantiD· 1 shared C. Bergonzi· 1 shared D. Daude· 1 shared Dominique MaderniD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Stephanou

Author profile →

4 papers

Recent·Most cited

Time-resolved functional rotation crystallography probes protein dynamics during enzymatic catalysis

Julien Martel, Nicolas Caramello, Sandrine Coquille, Eric Mathieu, Lucas Petit, P. Jacquet, Alexandre Appolaire, Filip Leonarski, Vincent Oliéric, Meitian Wang, Dominique Madern, Antoine Royant, Sylvain Engilberge

This paper introduces TR-FRX, a method to study protein dynamics during enzymatic catalysis using time-resolved crystallography, and applies it to lysozyme and malate dehydrogenase.

bioRxiv · Oct 3, 2026 · PreprintBiochemistry

A computational model of the spatiotemporal adaptation of tumor cells metabolism in a growing spheroid

A. Stephanou, P. Jacquet

This paper develops a computational model to simulate tumor spheroid metabolism, revealing spatiotemporal metabolic diversity and the role of acidity and pyruvate-lactate interactions in shaping tumor cell behavior.

bioRxiv · Sep 11, 2023 · PreprintCancer Biology

Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity

P. Jacquet, R. Billot, A. Shimon, N. Hoekstra, C. Bergonzi, A. Jenks, E. Chabriere, D. Daude, M. Elias

The paper redesigns the active site of lactonase SsoPox to enhance phosphotriester catalytic activity, revealing that loop conformation changes are critical for activity shifts.

bioRxiv · May 22, 2023Biochemistry

Why the tumor cell metabolism is not that abnormal

P. Jacquet, A. Stephanou

This paper presents a theoretical model of tumor cell metabolism showing that the Warburg effect is a transient adaptation to environmental stress, not an inherent tumor characteristic.

bioRxiv · Dec 4, 2019 · PreprintCell Biology