Author

A. Sljoka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:protein structure· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. P. Williamson· 2 shared N. J. Fowler· 2 shared A. Pandey· 1 shared D. Kozome· 1 shared D. Kuroda· 1 shared J. J. Gray· 1 shared J. R. Jeliazkov· 1 shared K. Tsumoto· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

M. P. Williamson

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Author profile →

5 papers

Recent·Most cited

Beyond the Active Site: The addition of a remote loop reveals a new complex biological function for chitinase enzymes.

D. Kozome, A. Sljoka, P. Laurino

This study identifies a remote loop in GH19 chitinase that enables antifungal activity through a defined structure, revealing a new mechanism for enzyme function evolution.

bioRxiv · Feb 27, 2023Biochemistry

Allosteric modulation of the adenosine A2A receptor by cholesterol

S. K. Huang, O. Almurad, R. J. Pejana, Z. A. Morrison, A. Pandey, L.-P. Picard, M. Nitz, A. Sljoka, R. S. Prosser

This study shows cholesterol weakly modulates A2AR conformation and signaling through indirect membrane effects rather than direct allosteric binding.

bioRxiv · Sep 13, 2021Biophysics

The accuracy of NMR protein structures in the Protein Data Bank

N. J. Fowler, A. Sljoka, M. P. Williamson

The paper evaluates NMR protein structures in the PDB using ANSURR, finding accuracy stagnated after 2005, with loops being too floppy and suggesting improvements through better experimental restraints.

bioRxiv · Apr 5, 2021Biophysics

A method for validating the accuracy of NMR protein structures

N. J. Fowler, A. Sljoka, M. P. Williamson

This paper introduces ANSURR, a method to assess NMR protein structure accuracy using residue-level comparisons of RCI and FIRST, and evaluates its performance against various structural metrics and decoys.

bioRxiv · Apr 20, 2020Biophysics

Repertoire analysis of antibody CDR-H3 loops suggests affinity maturation does not typically result in rigidification

J. R. Jeliazkov, A. Sljoka, D. Kuroda, N. Tsuchimura, N. Katoh, K. Tsumoto, J. J. Gray

The paper analyzes the flexibility of CDR-H3 loops in antibodies to assess if affinity maturation leads to rigidification, finding only a slight decrease in flexibility.

bioRxiv · Dec 8, 2017Biophysics