Author

M. P. Williamson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 4 Approach:deep learning· 3 Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Research Focus:benchmarking· 2 Approach:statistical model· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

N. J. Fowler· 4 shared A. M. Hounslow· 2 shared A. Sljoka· 2 shared , R. F. W. Jackson· 1 shared A. Hounslow· 1 shared B. Salamaga· 1 shared G. Bulmer· 1 shared J. Kołodziejczyk· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBiophysics

N. J. Fowler

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Author profile →

6 papers

Recent·Most cited

Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: the SH2 domain of SH2B1

N. J. Fowler, M. F. Albalwi, S. Lee, A. M. Hounslow, M. P. Williamson

The paper improves NMR structure calculation by incorporating hydrogen bond restraints and using ANSURR validation, resulting in more accurate SH2 domain structures.

bioRxiv · Aug 29, 2022Biophysics

The accuracy of protein structures in solution determined by AlphaFold and NMR

N. J. Fowler, M. P. Williamson

This study compares AlphaFold and NMR structures using ANSURR, finding AlphaFold more accurate in rigid regions but NMR better for dynamic structures.

bioRxiv · Jan 18, 2022Biophysics

The accuracy of NMR protein structures in the Protein Data Bank

N. J. Fowler, A. Sljoka, M. P. Williamson

The paper evaluates NMR protein structures in the PDB using ANSURR, finding accuracy stagnated after 2005, with loops being too floppy and suggesting improvements through better experimental restraints.

bioRxiv · Apr 5, 2021Biophysics

31P NMR Spectroscopy Demonstrates Large Amounts of Phosphohistidine in Mammalian Cells

M. V. Makwana, S. van Meurs, A. M. Hounslow, M. P. Williamson, , R. F. W. Jackson, R. Muimo

This paper quantifies phosphohistidine levels in mammalian cells using 31P NMR, finding it to be more abundant than phosphotyrosine but less than phosphoserine/phosphothreonine combined.

bioRxiv · Dec 3, 2020 · PreprintBiochemistry

A method for validating the accuracy of NMR protein structures

N. J. Fowler, A. Sljoka, M. P. Williamson

This paper introduces ANSURR, a method to assess NMR protein structure accuracy using residue-level comparisons of RCI and FIRST, and evaluates its performance against various structural metrics and decoys.

bioRxiv · Apr 20, 2020Biophysics

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and resistance to innate immunity

R. E. Smith, B. Salamaga, P. Szkuta, N. H. Hajdamowicz, T. K. Prajsnar, G. Bulmer, T. Fontaine, J. Kołodziejczyk, J.-M. Herry, A. Hounslow, M. P. Williamson, P. Serror, S. Mesnage

This study identifies the role of EPA decoration in E. faecalis virulence, cell surface charge, and resistance to innate immunity.

bioRxiv · Dec 6, 2018Microbiology