K. Tsumoto

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

Conformational features and interaction mechanisms of VHH antibodies with β-hairpin-like CDR-H3: A case of Nb8-HigB2 interaction.

This study investigates the conformational features and interaction mechanisms of a β-hairpin-like CDR-H3 in the VHH antibody Nb8, revealing key residues critical for structural stability and binding to HigB2.

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection

This study develops a biparatopic anti-TNFR2 antagonist that binds in a 1:1 ratio, preventing unwanted signal transduction and suppressing regulatory T cell proliferation.

Structural insights into 3Fe-4S ferredoxins diversity in M.tuberculosis highlighted by a first redox complex with P450.

The paper solves the structures of 3Fe-4S ferredoxins from M. tuberculosis and their complex with CYP143, revealing structural and functional insights into redox interactions.

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene

This study investigates how SNPs in the LI-cadherin gene affect cancer metastasis by weakening cell-cell adhesion through reduced homodimerization and altered hydrogen bonding.

Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex

This study compares the molecular interactions of the IL-11/IL-11R/gp130 complex with IL-6/IL-6R/gp130, revealing differences in thermodynamics and domain involvement that may explain distinct biological functions.

Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA.

This study uses lipid nanodiscs and surface plasmon resonance to identify a fragment compound that inhibits MsbA's ATPase activity, suggesting a pathway for developing stronger inhibitors.

Binding mechanism underlying FIH-1 suppression caused by the N-terminal disordered region of Mint3

This study investigates the binding mechanism between Mint3 and FIH-1, identifying a novel core site and thermodynamic contributions of Mint3's disordered region.

A new twist of rubredoxin function in M. tuberculosis

This study identifies RubB as a cofactor for mycobacterial cytochrome P450s in M. tuberculosis, showing its role in bacterial survival and potential biotech applications.

Dimerization mechanism and structural features of human LI-cadherin

This study determines the crystal structure of LI-cadherin EC1-4 homodimer and shows its unique architecture and noncanonical calcium ion-free linker, revealing the mechanism of homodimerization essential for cell adhesion.

Structural basis for binding mechanism of human serum albumin complexed with cyclic peptide dalbavancin

This study determines the crystal structure of human serum albumin bound to dalbavancin, revealing the binding mechanism and structural changes involved.

On-rate modulation of cadherin interactions by chemical fragments

This study identifies a chemical fragment that modulates the on-rate of P-cadherin dimerization by inhibiting cell adhesion.

Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome

This study shows that reduced Na+ channel expression in the lateral membrane of cardiomyocytes leads to phase-2 reentry, causing lethal arrhythmias in Brugada syndrome.

Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of spontaneous SR Ca2+ release

This study investigates the dynamical mechanisms of phase-2 early afterdepolarizations (EADs) in human ventricular myocytes using a modified ten Tusscher-Panfilov model, revealing two distinct EAD initiation mechanisms and their relationship to bifurcation phenomena.

Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias

This paper proposes that hERG channel facilitation by blockers can reduce lethal cardiac arrhythmias by preventing early afterdepolarizations during repolarization.

Repertoire analysis of antibody CDR-H3 loops suggests affinity maturation does not typically result in rigidification

The paper analyzes the flexibility of CDR-H3 loops in antibodies to assess if affinity maturation leads to rigidification, finding only a slight decrease in flexibility.

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.