The Meta-Position of Phe4 in Leu-enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors
R. J. Cassell, K. K. Sharma, H. Su, B. R. Cummins, H. Cui, K. L. Mores, A. T. Blaine, R. A. Altman, R. M. van Rijn
The paper investigates how substituting the meta-position of Phe4 in Leu5-enkephalin affects its binding affinity, signaling bias, and stability at delta and mu opioid receptors.
bioRxiv · Nov 20, 2019Pharmacology & Toxicology