R. M. van Rijn

The paper introduces ClickArr, a live-cell assay that measures β-arrestin isoform recruitment, showing agonists can have isoform bias.

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

The paper investigates how substituting the meta-position of Phe4 in Leu5-enkephalin affects its binding affinity, signaling bias, and stability at delta and mu opioid receptors.

The paper identifies naturally occurring rubiscolin peptides that selectively activate G-protein signaling at delta opioid receptors with minimal beta-arrestin recruitment.