A. Tewari

Transcriptional regulation of Dyskerin via canonical WNT signaling modulates sphingolipid biosynthesis and drives colorectal cancer.

This study identifies DKC1 as a key regulator in colorectal cancer progression through WNT signaling, showing its role in sphingolipid biosynthesis and proposing ceramides as potential biomarkers.

Unannotated small RNA clusters in circulating extracellular vesicles detect early stage liver cancer

The paper identifies a 3-smRC signature from circulating extracellular vesicles that detects early-stage liver cancer with high sensitivity and specificity.

A critical role for B cells in cancer immune surveillance

This study shows B cells are critical for anti-tumor immunity, challenging the belief that they are irrelevant in cancer immune surveillance.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

Human and mouse transcriptome profiling identifies cross-species homology in pulmonary and lymph node mononuclear phagocytes

The paper compares human and mouse mononuclear phagocyte gene expression to identify homologous subtypes and marker genes, finding limited overlap in top markers between species.