Author

A. Kapoor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. J. Marugan· 2 shared M. J. Henderson· 2 shared A. Allue Guardia· 1 shared A. Chandra· 1 shared A. Garcia-Sastre· 1 shared A. Garcia-Vilanova· 1 shared A. Gehrlein· 1 shared A. Glogowska· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

J. J. Marugan

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy

K. Shaikh, M. Bowman, S. M. McCormick, L. Gao, J. Zhang, J. Tawil, A. Kapoor, R. Arav-Boger, Y. B. Choi, A. Pekosz, S. L. Klein, M. Lanza, J. C. Fanburg-Smith, A. Garcia-Sastre, C. C. Norbury, , E. W. Harhaj

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.

bioRxiv · Mar 27, 2024 · PreprintImmunology

Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease

D. Williams, L. M. Glasstetter, T. T. Jong, A. Kapoor, S. Zhu, Y. Zhu, A. Gehrlein, D. J. Vocadlo, R. Jagasia, J. J. Marugan, E. Sidransky, M. J. Henderson, Y. Chen

This paper develops high-throughput assays to identify and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase, showing NCGC326 reverses pathological accumulation and synergizes with proteostasis regulators.

bioRxiv · Mar 22, 2024 · PreprintPharmacology & Toxicology

Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis

D. Ippolitov, Y.-H. Lin, J. Spence, A. Glogowska, T. Thanasupawat, J. Beiko, M. R. Del Bigio, X. Xu, A. Wang, R. Calvo, A. Kapoor, J. J. Marugan, M. J. Henderson, T. Klonisch, S. Hombach-Klonisch

This study establishes a patient-derived HER2+ brain metastasis model and identifies Poziotinib as an effective RTKi for treating HER2+ breast cancer brain metastasis in mice.

bioRxiv · Feb 19, 2024 · PreprintCancer Biology

Transcriptional regulation of Dyskerin via canonical WNT signaling modulates sphingolipid biosynthesis and drives colorectal cancer.

S. Nigam, U. K. Khan, A. Praveen, A. Shendre, S. Carskadon, A. Kapoor, A. Tewari, A. Chandra, N. Palanisamy, B. Ateeq

This study identifies DKC1 as a key regulator in colorectal cancer progression through WNT signaling, showing its role in sphingolipid biosynthesis and proposing ceramides as potential biomarkers.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmission

C. Ye, J.-G. Park, K. Chiem, P. Dravid, A. Allue Guardia, A. Garcia-Vilanova, A. kapoor, M. R. Walter, J. Kobie, R. K. Plemper, J. B. Torrelles, L. Martinez-Sobrido

This study develops a live-attenuated SARS-CoV-2 vaccine by deleting two accessory proteins, showing it protects against viral challenge and transmission in animal models.

bioRxiv · Mar 13, 2022 · PreprintMicrobiology

A Comparison of Macaque Hair Hormone Concentration Following Enhanced Cognitive Experiences or Standard Nonhuman Primate Environmental Enrichment

B. J. Meidam, E. K. Meredith, A. Kapoor, A. J. Bennett, P. J. Pierre

This study compares hormone concentrations in macaque hair following enhanced cognitive enrichment or standard environmental enrichment, finding no significant differences but suggesting potential impacts on stress hormone ratios.

bioRxiv · Dec 1, 2021 · PreprintZoology

Development and Validation of an LC-MS/MS Based Quantitative Assay for Marmoset Insulin

R. W. Goy, H. K. Shrestha, T. E. Ziegler, N. J. Dukes, R. J. Colman, A. Kapoor

This paper develops and validates an LC-MS/MS assay for quantifying marmoset insulin, achieving detection limits and physiological range validation.

bioRxiv · Jun 24, 2021Biochemistry

High-resolution Structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

S. Basak, A. Kumar, S. Ramsey, E. Gibbs, A. Kapoor, M. Filizola, S. Chakrapani

This study presents high-resolution cryo-EM structures of 5-HT3AR-setron complexes, revealing distinct interaction fingerprints and a novel mechanism of competitive inhibition.

bioRxiv · Mar 30, 2020Biophysics

Human Rotavirus Diarrhea Is Associated with Altered Trafficking and Expression of Apical Membrane Transport Proteins

N. C. Zachos, N. W. Baetz, A. Gupta, A. Kapoor, R. N. Cole, A. S. Verkman, J. R. Turner, M. K. Estes, M. Donowitz

bioRxiv · Sep 26, 2019 · PreprintCell Biology