This study identifies multiple genetic mechanisms of linezolid resistance in Staphylococcus aureus from cystic fibrosis patients, showing resistance developed in specific MRSA backgrounds.

bioRxiv · May 2, 2023 · PreprintMicrobiology

Measles virus exits human airway epithelia via infectious center sloughing

C. Hippee, B. Singh, A. Thurman, A. Cooney, A. Pezzulo, R. Cattaneo, P. L. Sinn

This paper identifies a novel mechanism by which measles virus exits human airway epithelia through sloughing of infectious centers, enhancing its transmissibility.

bioRxiv · Mar 9, 2021 · PreprintMicrobiology

Titration of in-cellula affinities of protein-protein interactions

D. Cluet, B. Vergier, N.-P. Levy, L. Dehau, A. Thurman, I. Amri, M. Spichty

The paper introduces a genetic assay using flow cytometry to quantify protein-protein interaction affinities at the single-cell level and demonstrates its application across diverse interactions.

bioRxiv · Apr 27, 2020 · PreprintBiochemistry

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

M. E. Ortiz Bezara, A. Thurman, A. A. Pezzulo, M. R. Leidinger, J. A. Klesney-Tait, P. H. Karp, P. Tan, C. Wohlford-Lenane, P. B. McCray, D. K. Meyerholz

This study examines ACE2 protein expression in the human respiratory tract using single-cell RNA sequencing and immunohistochemistry, finding it highest in sinonasal cavity and alveoli, and not correlated with severe COVID-19 risk factors.

bioRxiv · Apr 22, 2020Cell Biology