Author

D. K. Meyerholz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

M. R. Leidinger· 4 shared B. M. Ripley· 2 shared C. A. Kaemmer· 2 shared C. Wohlford-Lenane· 2 shared D. E. Quelle· 2 shared L. Radoshevich· 2 shared M. E. Ortiz Bezara· 2 shared P. B. McCray· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCancer Biology

M. R. Leidinger

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Enhanced ISGylation reduces respiratory distress following Francisella novicida infection

E. M. Upton, E. K. Luhmann, Y. Zhang, B. M. Ripley, D. K. Meyerholz, L. Radoshevich

This study shows that enhanced ISGylation reduces respiratory distress in Francisella novicida infection by modulating SAMHD1 function, suggesting USP18 inhibition as a therapeutic strategy.

bioRxiv · Sep 19, 2023 · PreprintMicrobiology

ISG15-modification of the Arp2/3 complex restricts pathogen spread

Y. Zhang, B. M. Ripley, W. Ouyang, M. Sturtz, E. Upton, E. Luhmann, M. Vessely, R. Coloma, N. Schwery, S. M. Anthony, A. Goeken, T. O. Moninger, J. T. Harty, A. J. Klingelhutz, E. Lundberg, , L. Radoshevich

This study shows ISG15 modifies the Arp2/3 complex to restrict pathogen spread by slowing actin filament formation and stabilizing structures, but pathogens like Listeria exploit dysregulated ISGylation to enhance spread.

bioRxiv · Dec 27, 2022 · PreprintCell Biology

Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo

J. L. Kohlmeyer, C. A. Kaemmer, J. J. Lingo, M. R. Leidinger, D. K. Meyerholz, M. R. Tanas, R. D. Dodd, D. E. Quelle

This study shows RABL6A promotes NF1-associated MPNST progression in vivo, with loss of RABL6A leading to slower tumor growth and upregulated p27, but also paradoxical Myc elevation and hyper-proliferative tumors.

bioRxiv · Jul 7, 2021Cancer Biology

RABL6A promotes pancreatic neuroendocrine tumor angiogenesis and progression in vivo

C. K. Maharjan, C. A. Kaemmer, V. P. Muniz, C. Bauchle, S. L. Mott, K. D. Zamba, P. Breheny, M. R. Leidinger, B. W. Darbro, S. Stephens, D. K. Meyerholz, D. E. Quelle

This study shows RABL6A promotes pancreatic neuroendocrine tumor angiogenesis and progression in vivo by affecting tumor formation, angiogenesis, and survival.

bioRxiv · Mar 17, 2021Cancer Biology

K18-hACE2 Mice for Studies of COVID-19 Treatments and Pathogenesis Including Anosmia

S. Perlman, J. Zheng, L. Y. R. WONG, K. Li, A. K. Verma, M. E. Ortiz Bezara, C. Wohlford-Lenane, M. R. Leidinger, M. C. Kundson, D. K. Meyerholz, P. B. McCray

This study uses K18-hACE2 mice to demonstrate severe SARS-CoV-2 infection in lungs and brains, thrombosis in severe cases, and the protective effect of convalescent plasma against lethal disease, while showing anosmia occurs independently of clinical outcome.

bioRxiv · Aug 7, 2020Microbiology

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

M. E. Ortiz Bezara, A. Thurman, A. A. Pezzulo, M. R. Leidinger, J. A. Klesney-Tait, P. H. Karp, P. Tan, C. Wohlford-Lenane, P. B. McCray, D. K. Meyerholz

This study examines ACE2 protein expression in the human respiratory tract using single-cell RNA sequencing and immunohistochemistry, finding it highest in sinonasal cavity and alveoli, and not correlated with severe COVID-19 risk factors.

bioRxiv · Apr 22, 2020Cell Biology