M. E. Ortiz Bezara

This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.

This study uses K18-hACE2 mice to demonstrate severe SARS-CoV-2 infection in lungs and brains, thrombosis in severe cases, and the protective effect of convalescent plasma against lethal disease, while showing anosmia occurs independently of clinical outcome.

This study examines ACE2 protein expression in the human respiratory tract using single-cell RNA sequencing and immunohistochemistry, finding it highest in sinonasal cavity and alveoli, and not correlated with severe COVID-19 risk factors.