Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration
E. Porpiglia, T. Mai, P. Kraft, C. A. Holbrook, A. De Morree, V. D. Gonzalez, K. Hilgendorf, L. Fresard, A. Trejo, S. Bhimaraju, P. K. Jackson, W. J. Fantl, H. M. Blau
This study identifies elevated CD47 in aged muscle stem cells as a marker of dysfunction and shows that targeting CD47 improves regeneration in aged mice.
bioRxiv · Apr 29, 2022Cell Biology