Author

C. A. Holbrook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. M. Blau· 2 shared Y. X. Wang· 2 shared A. Chang· 1 shared A. De Morree· 1 shared A. Kirillova· 1 shared A. Kundaje· 1 shared A. T. V. Ho· 1 shared A. Trejo· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

H. M. Blau

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Author profile →

3 papers

Recent·Most cited

Machine learning-based classification of binary dynamic fluorescence signals reveals muscle stem cell fate transitions in response to pro-regenerative niche factors

M. Togninalli, A. T. V. Ho, C. M. Madl, C. A. Holbrook, Y. X. Wang, K. E. G. Magnusson, A. Kirillova, A. Chang, H. Blau

This study uses machine learning to analyze dynamic fluorescence signals and classify muscle stem cell fate transitions in response to niche factors like PGE2 and OSM.

bioRxiv · Jun 17, 2022 · PreprintCell Biology

A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging

Y. X. Wang, C. A. Holbrook, J. N. Hamilton, J. Garoussian, M. Afshar, S. Su, C. M. Schurch, M. Y. Lee, Y. Goltsev, A. Kundaje, G. P. Nolan, H. M. Blau

The paper constructs a single cell spatial temporal atlas of skeletal muscle to reveal cellular neighborhoods involved in regeneration and their disruption in aging.

bioRxiv · Jun 10, 2022 · PreprintCell Biology

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

E. Porpiglia, T. Mai, P. Kraft, C. A. Holbrook, A. De Morree, V. D. Gonzalez, K. Hilgendorf, L. Fresard, A. Trejo, S. Bhimaraju, P. K. Jackson, W. J. Fantl, H. M. Blau

This study identifies elevated CD47 in aged muscle stem cells as a marker of dysfunction and shows that targeting CD47 improves regeneration in aged mice.

bioRxiv · Apr 29, 2022Cell Biology