Author

H. M. Blau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 4 Approach:deep learning· 3 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

C. A. Holbrook· 2 shared E. Porpiglia· 2 shared F. Birnbaum· 2 shared K. Koleckar· 2 shared P. K. Jackson· 2 shared P. Kraft· 2 shared Y. X. Wang· 2 shared A. C. Hinken· 1 shared

Activity by Year

2018-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

C. A. Holbrook

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Spatial compartmentalization of signalling imparts source-specific functions on secreted factors

F. M. Rossi, E. Groppa, P. Martini, N. Derakhshan, M. Theret, M. Ritso, L. W. Tung, Y. X. Wang, H. Soliman, M. S. Hamer, L. Stankiewicz, C. Eisner, E. Le Neve, C. Chang, L. Yi, , C. Romualdi

The paper identifies distinct functions of VEGFA from different cell types in skeletal muscle regeneration through time-resolved transcriptomic analysis and functional experiments.

bioRxiv · Aug 20, 2022 · PreprintCell Biology

A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging

Y. X. Wang, C. A. Holbrook, J. N. Hamilton, J. Garoussian, M. Afshar, S. Su, C. M. Schurch, M. Y. Lee, Y. Goltsev, A. Kundaje, G. P. Nolan, H. M. Blau

The paper constructs a single cell spatial temporal atlas of skeletal muscle to reveal cellular neighborhoods involved in regeneration and their disruption in aging.

bioRxiv · Jun 10, 2022 · PreprintCell Biology

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

E. Porpiglia, T. Mai, P. Kraft, C. A. Holbrook, A. De Morree, V. D. Gonzalez, K. Hilgendorf, L. Fresard, A. Trejo, S. Bhimaraju, P. K. Jackson, W. J. Fantl, H. M. Blau

This study identifies elevated CD47 in aged muscle stem cells as a marker of dysfunction and shows that targeting CD47 improves regeneration in aged mice.

bioRxiv · Apr 29, 2022Cell Biology

Single-cell mapping of tumor heterogeneity in pediatric rhabdomyosarcoma reveals developmental signatures with therapeutic relevance

S. G. Danielli, E. Porpiglia, A. J. De Micheli, N. Navarro, M. J. Zellinger, I. Bechtold, S. Kisele, L. Volken, J. G. Marques, S. Kasper, P. K. Bode, A. G. Henssen, D. Gürgen, J. Roma, P. Bühlmann, , B. W. Schäfer

This study maps tumor heterogeneity in pediatric rhabdomyosarcoma using single-cell data, revealing developmental signatures and identifying the RAS pathway as a therapeutic target.

bioRxiv · Apr 20, 2022 · PreprintCancer Biology

TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs

A. Eguchi, S. I. Torres-Bigio, K. Koleckar, A. F. G. S. Gonzalez, F. Birnbaum, H. M. Blau

This study shows that upregulating TRF2 in DMD cardiomyocytes from iPSCs increases telomere length and improves cell survival.

bioRxiv · Jan 10, 2022Cell Biology

Insights into single hiPSC-derived cardiomyocyte phenotypes and maturation using ConTraX, an efficient pipeline for tracking contractile dynamics

G. Pardon, H. Lewis, A. S. Vander Roest, E. A. Castillo, R. E. Wilson, A. K. Denisin, C. A. Blair, F. Birnbaum, C. Holbrook, K. Koleckar, A. C.-Y. Chang, H. M. Blau, B. Pruitt

The paper develops ConTraX, a pipeline to track contractile dynamics in single hiPSC-CMs, revealing maturation patterns through high-dimensional clustering.

bioRxiv · Mar 18, 2021 · PreprintBioengineering

Ciliation of muscle stem cells is critical to maintain regenerative capacity and is lost during aging

A. R. Palla, K. I. Hilgendorf, A. V. Yang, J. P. Kerr, A. C. Hinken, J. Demeter, P. Kraft, N. A. Mooney, N. Yucel, P. K. Jackson, H. M. Blau

This study identifies ciliary Hedgehog signaling as critical for muscle stem cell regeneration, showing that restoring it in aged mice improves muscle repair.

bioRxiv · Mar 20, 2020Cell Biology

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

S. C. Sampath, S. C. Sampath, A. T. Ho, S. Y. Corbel, J. D. Millstone, J. Lamb, J. Walker, B. Kinzel, C. Schmedt, H. M. Blau

This study identifies Oncostatin M as a secreted niche factor that induces muscle stem cell quiescence and maintains their regenerative capacity.

bioRxiv · Apr 18, 2018Cell Biology