A. Upadhyay

Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion

This study identifies novel SIRT3 activators that restore catalytic activity under NAD+ depletion, offering potential therapeutic applications for age-related diseases.

Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression

The paper demonstrates a genetically engineered insect system using sex-selection and genetic incompatibility for population suppression in Drosophila melanogaster.

Contrast-enhanced sonography with biomimetic lung surfactant nanodrops

This study uses biomimetic lung surfactant to stabilize microbubbles created from nanodrops for improved ultrasound imaging.

Nonallosteric Sirtuin Enzyme Activation: Characterization of Hit Compounds

The paper characterizes small molecules that nonallosterically activate SIRT3, identifying honokiol as a hit compound through computational and biochemical methods.

Mechanism-based enzyme activating compounds

The paper introduces new modes of enzyme activation based on catalytic mechanisms and presents simulations and experimental results supporting this framework.

Leaderless short ORFs in mycobacteria comprise a translational regulon

The paper identifies leaderless short ORFs in mycobacteria as functional translational regulators that control operon expression in response to cysteine availability.

Mechanism-based sirtuin enzyme activation

This paper identifies a general mechanism-based approach for activating sirtuin enzymes, challenges existing activation modes, and evaluates reported compounds for validity.