R. Chakrabarti

Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion

This study identifies novel SIRT3 activators that restore catalytic activity under NAD+ depletion, offering potential therapeutic applications for age-related diseases.

Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation

This study shows mitochondrial dysfunction triggers actin polymerization (ADA) to enable rapid glycolytic activation in multiple cell types.

Discovery of novel compounds as potent activators of Sirt3

This study identifies novel Sirt3 activators using DNA encoded library technology, showing potency comparable to Honokiol and atypical binding sites.

DNA amplification in mixed aqueous-organic media: chemical analysis of leading polymerase chain reaction compositions

The paper identifies and quantifies co-solvents in PCR buffers using GC/MS to improve amplification of GC-rich regions by understanding their effects on PCR efficiency and specificity.

Effect of Stapling on the Thermodynamics of mdm2-p53 Binding

This study examines how stapling affects the thermodynamics of mdm2-p53 peptide binding, showing improved binding affinity through entropic and enthalpic changes.

LncRNA PAINT is Associated with Aggressive Prostate Cancer and Dysregulation of Slug and Related Genes

This study identifies PAINT as an oncogenic lncRNA in prostate cancer that promotes progression by regulating EMT, apoptosis, and drug resistance.

Nonallosteric Sirtuin Enzyme Activation: Characterization of Hit Compounds

The paper characterizes small molecules that nonallosterically activate SIRT3, identifying honokiol as a hit compound through computational and biochemical methods.

Mechanism-based enzyme activating compounds

The paper introduces new modes of enzyme activation based on catalytic mechanisms and presents simulations and experimental results supporting this framework.

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors

The paper identifies two distinct actin filament populations with different assembly factors and effects on mitochondrial dynamics in response to calcium and depolarization.

Internal friction can be measured with the Jarzynski equality

The paper presents a protocol to measure internal friction in polymers using the Jarzynski equality, validated through simulations and feasible with optical tweezer techniques.

A complex containing lysine-acetylated actin inhibits the formin INF2

The paper identifies a complex of lysine-acetylated actin and CAP as an inhibitor of INF2, revealing a novel mechanism of facilitated auto-inhibition linked to disease.

Persistence of Resident and Transplanted Genotypes of the Undomesticated Yeast, Saccharomyces paradoxus in Forest Soil

This study shows that Saccharomyces paradoxus and S. cerevisiae persist in forest soil over years, with abundance fluctuating with rainfall and drought.

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum

This paper identifies ER-associated Drp1 oligomers formed via Mff and shows their role in mitochondrial division.

Mechanism-based sirtuin enzyme activation

This paper identifies a general mechanism-based approach for activating sirtuin enzymes, challenges existing activation modes, and evaluates reported compounds for validity.