Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans
A. V. Kumar, J. Mills, W. M. Parker, J. Leitao, D. I. Rodriguez, C. Ng, R. Patel, J. L. Aguilera, J. R. Johnson, S. Q. Wong, L. R. Lapierre
This study identifies lipid droplets as a proteostatic mediator in C. elegans that reduces protein ubiquitination, facilitates autophagy, and extends lifespan.
bioRxiv · Apr 22, 2021Cell Biology