Author

L. R. Lapierre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Jongejan· 1 shared A. V. Kumar· 1 shared A. W. Gao· 1 shared A. W. MacInnes· 1 shared C. Ng· 1 shared D. I. Rodriguez· 1 shared D. M. Panneman· 1 shared F. M. Vaz· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Jongejan

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Author profile →

3 papers

Recent·Most cited

Ubiquitinated protein levels remain high during ageing in C. elegans

S. E. Daigle, S. Doucet, L. R. Lapierre

This study reanalyzes proteostasis in C. elegans and finds that polyubiquitinated protein levels remain constant with age, contradicting a previous conclusion.

bioRxiv · Nov 7, 2023 · PreprintBiochemistry

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

A. V. Kumar, J. Mills, W. M. Parker, J. Leitao, D. I. Rodriguez, C. Ng, R. Patel, J. L. Aguilera, J. R. Johnson, S. Q. Wong, L. R. Lapierre

This study identifies lipid droplets as a proteostatic mediator in C. elegans that reduces protein ubiquitination, facilitates autophagy, and extends lifespan.

bioRxiv · Apr 22, 2021Cell Biology

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

Y. J. Liu, A. W. Gao, R. L. Smith, G. E. Janssens, D. M. Panneman, A. Jongejan, M. van Weeghel, F. M. Vaz, M. J. Silvestrini, L. R. Lapierre, A. W. MacInnes, R. H. Houtkooper

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

bioRxiv · Nov 2, 2020 · PreprintCell Biology