J. R. Johnson

Insects visit Fusarium xyrophilum pseudoflowers on the host Xyris surinamensis (Xyridaceae) and carry fungal DNA on their bodies

The paper investigates whether Fusarium xyrophilum pseudoflowers attract insects for dispersal by analyzing insect visitation, fungal DNA on insects, and volatile compounds.

Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa

This study identifies a spatial mechanism of sensory adaptation in Pseudomonas aeruginosa, revealing how enzyme localization modulates mechanosensing and virulence.

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

Hyperglycemia increases the severity of Staphylococcus aureus osteomyelitis and influences bacterial genes required for survival in bone.

This study shows hyperglycemia worsens Staphylococcus aureus osteomyelitis and identifies genes critical for bacterial survival in high glucose environments.

Immunological landscape of human lymphoid explants during measles virus infection

The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.

Chlamydia trachomatis effector Dre1 interacts with dynactin to reposition host organelles during infection

This study identifies Dre1, a Chlamydia effector that interacts with dynactin to reposition host organelles during infection, enhancing bacterial fitness.

SARS-CoV-2 hijacks p38β/MAPK11 to promote viral protein translation

This study identifies p38β as a critical host factor for SARS-CoV-2 replication and shows that inhibiting it reduces viral replication and cytokine production.

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

This study identifies lipid droplets as a proteostatic mediator in C. elegans that reduces protein ubiquitination, facilitates autophagy, and extends lifespan.

Synthetic biology meets proteomics: Construction of a la carte QconCATs for absolute protein quantification

The paper introduces a method to construct customizable QconCATs for proteomic quantification using synthetic biology principles.

Endosomal cAMP production broadly impacts the cellular phosphoproteome

The paper shows that endosomal cAMP production leads to distinct phosphoproteomic changes compared to plasma membrane cAMP, with a strong bias toward dephosphorylation by PP2A-B56{delta}.

A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

The paper constructs a tyrosine kinase protein interaction map, revealing EGFR network oncogenesis in 19% of EGFR wild-type lung cancers, which is targetable with EGFR inhibitors.

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

This study uses proteomics to analyze post-translational modifications in macrophages infected with three intracellular pathogens, revealing pathogen-specific molecular responses and a novel mechanism of virus-bacterial synergy.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

Peptidoglycan sensing prevents quiescence and promotes quorum-independent growth of uropathogenic Escherichia coli

This study shows that peptidoglycan sensing prevents quiescence and promotes growth in uropathogenic E. coli, with L-lysine and PG peptides acting as proliferants.

Chaperone-Mediated Reflux of Secretory Proteins to the Cytosol During Endoplasmic Reticulum Stress

The paper identifies a chaperone-mediated process that refuxes properly folded ER proteins to the cytosol during ER stress, functioning parallel to ERAD.

Global proteomic profiling of primary macrophages during M. tuberculosis infection identifies TAX1BP1 as a mediator of autophagy targeting

The paper uses proteomic analysis to identify TAX1BP1 as a mediator of autophagy targeting M. tuberculosis during macrophage infection.

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

Emergence of enteroaggregative Escherichia coli within the ST131 lineage as a cause of extraintestinal infections

The paper identifies a new ST131 E. coli sublineage with enteroaggregative traits causing extraintestinal infections and outbreaks in Denmark.