Pro-inflammatory cytokines disrupt β-cell circadian clocks in diabetes
N. Javeed, M. R. Brown, K. Rakshit, T. Her, Z. Ye, J. H. Lee, T. Ordog, A. V. Matveyenko
This study shows that IL-1β disrupts β-cell circadian clocks by impairing Bmal1 expression and alters its DNA-binding patterns, linking circadian disruption to β-cell failure in diabetes.
bioRxiv · Aug 15, 2019 · PreprintCell Biology