Author

A. S. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. V. Sharrock· 1 shared C. N. Horvat· 1 shared D. F. Ackerley· 1 shared D. Pitsch· 1 shared D. Wachten· 1 shared E. Hanssen· 1 shared E. Hartland· 1 shared E. M. Williams· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. V. Sharrock

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Opposing roles of resident and infiltrating immune cells in the defence against Legionella longbeachae via IL-18R/IFN-γ/ROS axis

L. M. Oberkircher, V. M. Scheiding, H. L. Rafeld, E. Hanssen, J. N. Hansen, M. J. Fleischmann, N. M. Kessler, D. Pitsch, D. Wachten, W. Kastenmueller, A. S. Brown, E. Hartland, I. R. van Driel, G. Z. Ng, N. Garbi

This study identifies opposing roles of tissue-resident alveolar macrophages and infiltrating neutrophils/monocyte-derived cells in controlling Legionella longbeachae infection via the IL-18R/IFN-γ/ROS pathway.

bioRxiv · Jan 31, 2024 · PreprintImmunology

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

M. H. Rich, A. V. Sharrock, T. S. Mulligan, F. Matthews, A. S. Brown, H. R. Lee-Harwood, E. M. Williams, J. N. Copp, R. F. Little, J. J. Francis, C. N. Horvat, L. J. Stevenson, J. G. Owen, M. T. Saxena, J. S. Mumm, D. F. Ackerley

This paper introduces a metagenomic library cloning strategy using partial digestion with Fatl to enhance gene expression, enabling the discovery of nitroreductases with novel functions.

Cell Chemical Biology · Dec 1, 2023Peer-reviewedBiochemistry