The Drosophila Tumour Suppressor Lgl and Vap33 activate the Hippo pathway by a dual mechanism, involving RtGEF/Git/Arf79F and inhibition of the V-ATPase.
H. E. Richardson, M. Portela, S. Mukherjee, S. Paul, J. E. La Marca, L. M. Parsons, A. Veraksa
This study shows Lgl activates the Hippo pathway via Vap33 through two mechanisms: interacting with RtGEF/Git/Arf79F and inhibiting V-ATPase activity.
bioRxiv · Jul 10, 2023Cell Biology