Cervicovaginal tissue residence imprints a distinct differentiation program upon memory CD8 T cells
V. Dave, E. F. Cardozo Ojeda, F. Mair, J. Erickson, A. Woodward-Davis, A. Soerens, A. Koehne, J. Czartoski, C. Teague, N. Potchen, S. Oberle, D. Zehn, J. Schiffer, J. M. Lund, M. Prlic
The paper shows that residence in cervicovaginal tissue shapes CD8 T cell phenotype and function, leading to reduced local immunity and impaired viral control upon secondary challenge.
bioRxiv · Apr 23, 2020 · PreprintImmunology