Author

S. Oberle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1

Frequent Co-Authors

D. Zehn· 4 shared A. Drobek· 1 shared A. Koehne· 1 shared A. Moudra· 1 shared A. Soerens· 1 shared A. Woodward-Davis· 1 shared C. Teague· 1 shared D. Mueller· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersImmunology

D. Zehn

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4 papers

Recent·Most cited

T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

S. S. Chin, E. Guillen, L. Chorro, S. Achar, S. Oberle, K. Ng, F. Alfei, D. Zehn, G. Altan-Bonnet, F. DELAHAYE, G. Lauvau

This study shows that TCR and IL-2 signaling strength during vaccination epigenetically programs memory CD8+ T cell functional fitness through chromatin remodeling.

bioRxiv · Oct 19, 2021Immunology

Cervicovaginal tissue residence imprints a distinct differentiation program upon memory CD8 T cells

V. Dave, E. F. Cardozo Ojeda, F. Mair, J. Erickson, A. Woodward-Davis, A. Soerens, A. Koehne, J. Czartoski, C. Teague, N. Potchen, S. Oberle, D. Zehn, J. Schiffer, J. M. Lund, M. Prlic

The paper shows that residence in cervicovaginal tissue shapes CD8 T cell phenotype and function, leading to reduced local immunity and impaired viral control upon secondary challenge.

bioRxiv · Apr 23, 2020 · PreprintImmunology

Attenuation of chronic antiviral T cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

K. Schaeuble, H. Cannelle, S. Favre, H.-Y. Huang, S. Oberle, D. Zehn, S. A. Luther

The paper identifies lymph node fibroblastic reticular cells (FRC) as a source of COX2-dependent PGE2 that suppresses T cell responses during chronic infection.

bioRxiv · Oct 30, 2018Immunology

Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells

A. Drobek, A. Moudra, D. Mueller, M. Huranova, V. Horkova, M. Pribikova, R. Ivanek, S. Oberle, D. Zehn, K. D. McCoy, P. Draber, O. Stepanek

The paper shows that virtual memory CD8 T cells arise from strongly self-reactive T cells and are regulated by CD8-Lck stoichiometry, but do not exhibit increased autoimmune potential.

bioRxiv · Oct 13, 2017Immunology