Author

A. X. Spittel

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Biophysics· 1

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Approach:experimental assay· 1

Frequent Co-Authors

A. des Georges· 1 shared D. J. Weber· 1 shared D. L. Abeyawardhane· 1 shared E. Pozharski· 1 shared I. F. Nawaz· 1 shared K. A. Adipietro· 1 shared K. M. Varney· 1 shared R. Godoy-Ruiz· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

A. des Georges

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1 paper

Recent·Most cited

Membrane binding and pore formation is Ca2+-dependent for the Clostridioides difficile binary toxin

D. L. Abeyawardhane, S. E. Sevdalis, K. A. Adipietro, R. Godoy-Ruiz, K. M. Varney, I. F. Nawaz, A. X. Spittel, R. R. Rustandi, V. I. Silin, A. des Georges, E. Pozharski, D. J. Weber

This study shows that Ca2+ dissociation from CDTb's RBD1 triggers pore formation in endosomal membranes, differing from other binary toxins that rely on pH changes.

bioRxiv · Aug 18, 2023 · PreprintBiophysics