Membrane binding and pore formation is Ca2+-dependent for the Clostridioides difficile binary toxin
D. L. Abeyawardhane, S. E. Sevdalis, K. A. Adipietro, R. Godoy-Ruiz, K. M. Varney, I. F. Nawaz, A. X. Spittel, R. R. Rustandi, V. I. Silin, A. des Georges, E. Pozharski, D. J. Weber
This study shows that Ca2+ dissociation from CDTb's RBD1 triggers pore formation in endosomal membranes, differing from other binary toxins that rely on pH changes.
bioRxiv · Aug 18, 2023 · PreprintBiophysics