Author

R. Godoy-Ruiz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

D. J. Weber· 2 shared A. des Georges· 1 shared A. X. Spittel· 1 shared B. Ruan· 1 shared D. A. Rozak· 1 shared D. L. Abeyawardhane· 1 shared D. T. Gallagher· 1 shared E. A. Toth· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

D. J. Weber

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2 papers

Recent·Most cited

Membrane binding and pore formation is Ca2+-dependent for the Clostridioides difficile binary toxin

D. L. Abeyawardhane, S. E. Sevdalis, K. A. Adipietro, R. Godoy-Ruiz, K. M. Varney, I. F. Nawaz, A. X. Spittel, R. R. Rustandi, V. I. Silin, A. des Georges, E. Pozharski, D. J. Weber

This study shows that Ca2+ dissociation from CDTb's RBD1 triggers pore formation in endosomal membranes, differing from other binary toxins that rely on pH changes.

bioRxiv · Aug 18, 2023 · PreprintBiophysics

Engineering protein-specific proteases: targeting active RAS

Y. Chen, E. A. Toth, B. Ruan, E. J. Choi, R. Simmerman, Y. Chen, Y. He, R. Wang, R. Godoy-Ruiz, H. King, G. Custer, D. T. Gallagher, D. A. Rozak, M. Soloman, S. Muro, , P. N. Bryan

This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.

bioRxiv · Sep 21, 2020Biochemistry