Oxidation of ΔFOSB at Cys172 Controls Hippocampal Gene Targets and Learning
Haley M. Lynch, Daniela Anderson, Brandon W. Hughes, Galina V. Aglyamova, Szu-Ying Yeh, Yoshinori N. Onishi, Molly S. Estill, Bryan Granger, Hannah M. Cates, Stefano Berto, Jeannie Chin, Li Shen, Eric J. Nestler, Gabby Rudenko, A.J. Robison
This study shows that oxidation of ΔFOSB at Cys172 regulates its DNA binding and gene expression in the hippocampus, affecting cognitive function under oxidative stress.
bioRxiv · Oct 14, 2025 · PreprintNeuroscience