Jeannie Chin

Microglia-Specific Molecular Magnetic Resonance Imaging Probe Enables Noninvasive Separation of Parkinsonian Mice from Controls

A microglia-targeted MRI probe distinguishes Parkinsonian mice from controls by generating disease-specific contrast through radiomics analysis.

Early-Stage Corticostriatal Circuit Hyperactivity Impairs Cholinergic Function and Cognitive Flexibility in an Alzheimer's Model

This paper identifies hyperactivity in the mPFC-to-DMS circuit in 5xFAD mice as a cause of cognitive inflexibility, showing that inhibiting this circuit improves cognitive function and reduces Aβ accumulation.

Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor DeltaFOSB

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

Efficient in vivo pharmacological inhibition of deltaFOSB, an AP1 transcription factor, in brain

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

Oxidation of ΔFOSB at Cys172 Controls Hippocampal Gene Targets and Learning

This study shows that oxidation of ΔFOSB at Cys172 regulates its DNA binding and gene expression in the hippocampus, affecting cognitive function under oxidative stress.

A dual target molecular MRI probe for noninvasive profiling of pathologic alpha-synuclein and microgliosis in a mouse model of Parkinson's disease

HIV-1 gp120 impairs spatial memory through CREB

This study shows HIV-1 gp120 impairs spatial memory by inhibiting CREB activity, leading to mitochondrial dysfunction and synaptic plasticity loss.

TRPM4 conductances in thalamic reticular nucleus neurons generate persistent firing during slow oscillations

This study identifies TRPM4 channels as critical for persistent firing in TRN neurons during slow oscillations, revealing both cell-intrinsic and synaptic mechanisms underlying thalamic rhythmic activity.