Gabby Rudenko

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

This study shows that oxidation of ΔFOSB at Cys172 regulates its DNA binding and gene expression in the hippocampus, affecting cognitive function under oxidative stress.