Brandon W. Hughes

This paper introduces a unified preclinical focused ultrasound platform validated across in vitro, ex vivo, and awake in vivo models for therapeutic applications.

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

The paper uses CRISPR-based epigenetic editing to manipulate Cartpt expression in mice, showing it affects cocaine memory acquisition and extinction.

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

This study shows that oxidation of ΔFOSB at Cys172 regulates its DNA binding and gene expression in the hippocampus, affecting cognitive function under oxidative stress.

This study examines RyR2 expression and localization in the vmPFC during drug and sucrose self-administration and reward recall, finding that drug recall alters RyR2P distribution and increases its somatic expression.

This study shows that NPAS4 in the medial prefrontal cortex is required for chronic social defeat stress-induced anhedonia and dendritic spine loss, but not social avoidance or anxiety-like behavior.

This study shows NPAS4 regulates drug-cue associations and relapse-like behavior by controlling the activation balance between D1- and D2-MSNs in the nucleus accumbens.