Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface
Sanjay Kumar Mohanty, Aayushi Mittal, Namra, Aakash Gaur, Subhadeep Duari, Saveena Solanki, Anmol Kumar Sharma, Sakshi Arora, Suvendu Kumar, Vishakha Gautam, Nilesh Kumar Dixit, Karthika Subramanian, Tarini Shankar Ghosh, Debarka Sengupta, Shashi Kumar Gupta, , Gaurav Ahuja
The paper identifies endogenous sterols as intracellular allosteric modulators of the GPCR-Gα interface using a deep learning toolkit and experimental validation.
eLife · Dec 8, 2025Peer-reviewedBioinformatics