Kalyan Mitra

Cryptic Genes as Building Blocks of Antimicrobial Resistance: Evidence from a Novel Marine Imipenem-Hydrolyzing Metallo-β-Lactamase

The paper identifies a novel cryptic metallo-beta-lactamase gene in a marine bacterium that hydrolyzes imipenem, highlighting its potential role in antimicrobial resistance.

Host cell plasma membrane-derived vesicles efficiently inhibit in vitro Influenza A virus infection in a size-dependent manner

This study shows that plasma membrane-derived vesicles inhibit Influenza A virus infection in a size-dependent manner by competitively binding to hemagglutinin.

KAT5 Acetylates Human Chromatin Protein PC4 to promote DNA Repair

This study shows that KAT5 acetylates PC4 at K80 to enhance DNA repair, and this acetylation is critical for DNA damage response.

T13F2.2 of C. elegans is Critical for Chromatin Organization, Autophagy, and Longevity

This study identifies T13F2.2 as a critical gene in C. elegans that affects chromatin structure, autophagy, and lifespan through RNAi depletion and transcriptomic analysis.

Inflammasomes and DNA Damage Orchestrate Divergent Pyroptotic Fates in Neutrophils

This study investigates pyroptotic responses in neutrophils under different conditions, revealing distinct mechanisms involving inflammasomes, DNA damage, and actomyosin forces that determine cytokine secretion or cell death.

Sca-1 expression depicts pro-inflammatory murine neutrophils under steady state and pathological conditions

This study identifies a novel Sca1pos neutrophil subset with pro-inflammatory properties in both steady state and inflammatory conditions.

M6A reader protein YTHDF3 regulates cardiomyocyte death and atrophy by modulating the alternative splicing program

This study shows YTHDF3 regulates cardiomyocyte death and atrophy by modulating alternative splicing, particularly of CaMKIIδ, in the heart.

Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis

This study shows that inhibiting the mitochondrial calcium uniporter reduces fibroblast-like synoviocytes migration and mitochondrial dysfunction in rheumatoid arthritis.

In vitro and in vivo synergy of Vancomycin and β-lactams against drug-resistant Mycobacterium tuberculosis and Non-tuberculous mycobacteria

This study identifies synergistic combinations of Vancomycin and β-lactams against drug-resistant mycobacteria, showing improved bactericidal activity and reduced bacterial load in vitro and in vivo.