Regulatory T cells crosstalk with tumor and endothelium through lymphotoxin signaling
Wenji Piao, Long Wu, Yanbao Xiong, Gregory C. Zapas, Christina M. Paluskievicz, Robert S. Oakes, Sarah M. Pettit, Margaret L. Sleeth, Keli Lee Hippen, Jessica Schmitz, Philipp Ivanyi, Amol Carl Shetty, Yang Song, Dejun Kong, Young Lee, , Jonathan S. Bromberg
This study identifies Treg-mediated lymphotoxin signaling that promotes tumor growth and metastasis by activating nonclassical NFκB pathways in tumor and endothelial cells, and shows that targeting this pathway can suppress tumor progression.
Nature Communications · Dec 2, 2024Peer-reviewedCancer Biology