Christopher M. Jewell

PEGylation strategies for enhanced nanoparticle delivery to tumor associated immune cells

This study evaluates how linear and branched PEGylation affects nanoparticle uptake and distribution in tumor and immune cells, showing branched PEG increases spleen accumulation and linear PEG enhances tumor uptake by immune cells.

Bacterial extracellular vesicles as a tunable platform for vaginal drug delivery

This study evaluates bacterial extracellular vesicles as a tunable platform for vaginal drug delivery, showing effective protein loading and retention in the murine reproductive tract without adverse effects.

Regulatory T cells crosstalk with tumor and endothelium through lymphotoxin signaling

This study identifies Treg-mediated lymphotoxin signaling that promotes tumor growth and metastasis by activating nonclassical NFκB pathways in tumor and endothelial cells, and shows that targeting this pathway can suppress tumor progression.