Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset on Alzheimer's disease-related neurpathology
Aaron del Pozo, Kevin M. Knox, Leanne M Lehmann, Stephanie Davidson, S Rho, Suman Jayadev, Melissa L. Barker‐Haliski
This study shows that chronic seizures in pre-symptomatic APP/PS1 mice worsen Alzheimer's disease-related pathology and serotonin pathway disruptions without amyloid β plaque formation.
bioRxiv · Jan 5, 2023Neuroscience