Kevin M. Knox

A Humanized Mouse Model of DRPLA Recapitulates Epilepsy and Demonstrates Antisense Oligonucleotide-Mediated Disease Modification

This study uses a humanized mouse model to show that antisense oligonucleotides reduce seizure activity and mortality in DRPLA.

Acute Dose-Related Effect of Antiseizure Medicines on Open Field Exploration of Male Rats with Established Epilepsy

This study examines the acute dose-related effects of antiseizure medicines on behavior in rats with epilepsy, finding varying impacts on locomotion and exploration.

Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine activity in aged mice

This study investigates how Alzheimer's disease-associated genotypes affect seizure outcomes and antiseizure medication efficacy in aged mice, finding differential responses to specific drugs.

Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection-induced acute seizures

This study examines how diet and sterilization affect gut microbiome diversity and acute seizure incidence in TMEV-infected mice, finding diet impacts seizure frequency and behavioral outcomes.

Chronic Seizures Induce Sex-Specific Cognitive Deficits with Loss of Presenilin 2 Function

This study shows chronic seizures worsen cognitive deficits in aged female PSEN2 KO mice but not males, with sex-specific changes in neuroinflammation and neuroplasticity.

Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset on Alzheimer's disease-related neurpathology

This study shows that chronic seizures in pre-symptomatic APP/PS1 mice worsen Alzheimer's disease-related pathology and serotonin pathway disruptions without amyloid β plaque formation.

Continuous Seizure Emergency Evoked in Mice with Pharmacological, Electrographic, and Pathological Features Distinct from Status Epilepticus

This paper introduces a novel mouse model of sustained seizure emergency with distinct pharmacological, electrographic, and pathological features compared to status epilepticus.

Development of an Antiepileptogenesis Drug Screening Platform: Effects of Everolimus and Phenobarbital

This paper describes a moderate-throughput drug screening platform in a rat model of temporal lobe epilepsy to evaluate antiepileptogenic agents, finding no significant effect of everolimus or phenobarbital on preventing spontaneous recurrent seizures.