Author

Leanne M Lehmann

University of WashingtonORCID 0000-0002-9297-7809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Melissa L. Barker‐HaliskiiD· 3 shared Kevin M. KnoxiD· 2 shared Stephanie Davidson· 2 shared Suman JayadeviD· 2 shared Aaron del Pozo· 1 shared Alexandria Lo· 1 shared Anna Y Dai-Liu· 1 shared Daniel Muñoz-MayorgaiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Melissa L. Barker‐HaliskiORCID

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4 papers

Recent·Most cited

Pregnancy History and Loss of Normal PSEN2 Function Impact Female Late-Life Cognitive Processing, Inhibitory Signaling, and Gliosis

Jennie Isabella Fang, Leanne M Lehmann, Katherine E. Prater, Melissa L. Barker‐Haliski

The paper investigates how pregnancy history and PSEN2 deficiency affect cognitive function and neurobiology in aged female mice, finding no synergistic effects.

bioRxiv · Oct 30, 2026 · PreprintNeuroscience

Ketone body beta-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanism

Leigh-Ana M. Rossitto, Jamie Foo, Julia M Di Silvestri, Leanne M Lehmann, Melina Brunelli, Yuhang Nie, Daniel Muñoz-Mayorga, Qiang Xiao, Anna Y Dai-Liu, Suborno Jati, Meghan Rossi, Richard Daneman, Jeffery W. Kelly, John C. Newman, Samuel A. Myers, Xu Chen

This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.

bioRxiv · Feb 2, 2026 · PreprintNeuroscience

Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine activity in aged mice

Kevin M. Knox, Stephanie Davidson, Leanne M Lehmann, Erica Skinner, Alexandria Lo, Suman Jayadev, Melissa L. Barker‐Haliski

This study investigates how Alzheimer's disease-associated genotypes affect seizure outcomes and antiseizure medication efficacy in aged mice, finding differential responses to specific drugs.

bioRxiv · Oct 6, 2024 · PreprintNeuroscience

Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset on Alzheimer's disease-related neurpathology

Aaron del Pozo, Kevin M. Knox, Leanne M Lehmann, Stephanie Davidson, S Rho, Suman Jayadev, Melissa L. Barker‐Haliski

This study shows that chronic seizures in pre-symptomatic APP/PS1 mice worsen Alzheimer's disease-related pathology and serotonin pathway disruptions without amyloid β plaque formation.

bioRxiv · Jan 5, 2023Neuroscience