Structural basis for multiple binding modes of antimalarial ligands targeting Plasmodium falciparum NCR1
Aaron Kohling, Coralie Boulet, Mounaf Al Makhlouf, Basavraj Khanppnavar, Ya Chen, Emma Ganga, Johannes Kirchmair, Thomas Stockner, Mathieu Brochet, Volodymyr M. Korkhov
The paper reports cryo-EM structures of PfNCR1 bound to four inhibitors, revealing distinct binding modes that inform drug discovery targeting this malaria parasite transporter.
bioRxiv · Nov 11, 2025 · PreprintBiochemistry