Author

Ya Chen

University of ViennaORCID 0000-0001-5273-1815Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

Johannes KirchmairiD· 2 shared Aaron Kohling· 1 shared Alexander F. PerhaliD· 1 shared Basavraj KhanppnavariD· 1 shared Coralie BouletiD· 1 shared Emma GangaiD· 1 shared Jasmin JanneschütziD· 1 shared Judith Maria RollingeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

Johannes KirchmairORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)

Patrik F. Schwarz, Alexander F. Perhal, Teresa Preglej, Lina Breit, Klaus G. Schmetterer, Ulrike Grienke, Jasmin Janneschütz, Ya Chen, Natacha Rochel, Johannes Kirchmair, Nina Schützenmeister, Judith Maria Rollinger, Michael Markus Bonelli, Verena Maria Dirsch

This study identifies primulagenin A as a potent inverse agonist of RORγ, showing efficacy in inhibiting Th17 cell differentiation and reducing IL-17A production.

Acta Pharmaceutica Sinica B · Mar 14, 2026Peer-reviewedPharmacology & Toxicology

Structural basis for multiple binding modes of antimalarial ligands targeting Plasmodium falciparum NCR1

Aaron Kohling, Coralie Boulet, Mounaf Al Makhlouf, Basavraj Khanppnavar, Ya Chen, Emma Ganga, Johannes Kirchmair, Thomas Stockner, Mathieu Brochet, Volodymyr M. Korkhov

The paper reports cryo-EM structures of PfNCR1 bound to four inhibitors, revealing distinct binding modes that inform drug discovery targeting this malaria parasite transporter.

bioRxiv · Nov 11, 2025 · PreprintBiochemistry