Thomas Stockner

The paper reports cryo-EM structures of PfNCR1 bound to four inhibitors, revealing distinct binding modes that inform drug discovery targeting this malaria parasite transporter.

This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.

This study identifies betaine as a slow substrate of GAT1, showing it modulates GABA reuptake and helps maintain GABA homeostasis, protecting neurons from excitotoxicity.

This study identifies a novel sodium recruiting site in GAT1 and shows how sodium binding stabilizes the transporter's conformation and enhances GABA uptake.