Casp1 and Ripk3 are required for homeostatic insulin secretion in mice
Madison D. Girouard, Conor O’Dwyer, Cassandra A.A. Locatelli, Myriam P Hoyeck, Evgenia Fadzeyeva, Tyler K.T. Smith, Rui Yan Gao, Tanvi Ahluwalia, Sophia M. Perrakis, Andrew C. Clément, Antonio A. Hanson, Peyman Ghorbani, Lili Grieco-St-Pierre, Jianfan Nie, Mariam Hakoum, , Morgan D. Fullerton
This study shows that deleting both Casp1 and Ripk3 in mice improves glucose-stimulated insulin secretion, independent of cell death or inflammation.
bioRxiv · Sep 4, 2026 · PreprintPhysiology